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MOTS-C

MOTS-C

Certificate of Analysis

Third-party tested for 99% purity, ID, quantity.

Certificate of Analysis

Third-party tested for endotoxins

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20 mg

Synthetic peptide, 16 residues. Reference material for in vitro laboratory research use only.

 Compound MOTS-c
 CAS 1627580-64-6
 Sequence (1-letter) MRWQEMGYIFYPRKLR
 Sequence (3-letter) Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg
 Molecular formula C101H152N28O22S2
 Molecular weight 2174.6 g/mol
 Net content 20 mg per vial (gross fill; actual content per lot COA)
 Form Lyophilized powder
 Storage ?20 °C or colder, desiccated, protected from light and air; contains two methionine residues and is susceptible to oxidation
 Testing Identity and purity verified by third-party HPLC analysis; a lot-specific Certificate of Analysis is provided with each order.

Research Use Only. Not a drug, supplement, or food. Not for human or veterinary use. Not intended to diagnose, treat, cure, or prevent any disease.

MOTS-C Structure

Chemical Structure Diagram

CAS: #1627580-64-6
Molecular Formula: C???H???N??O??S?
Molecular Weight: 2171.5 g/mol
PubChem ID: 91808068

Research Findings

MOTS-c has been studied in mitochondrial, molecular, and systemic models, with research highlighting its role in mitochondrial function, AMPK pathway activation, and signaling dynamics. Studies also report activity in substrate utilization, downstream markers, and molecular stress responses in preclinical settings.

Key Areas of Research:

  • Mitochondrial: AMPK, signaling, pathway dynamics

  • Molecular: Mitochondrial function, stress response, remodeling

  • Systemic: Signaling, resilience, viability

Together, these findings suggest broad experimental potential for MOTS-c across mitochondrial, molecular, and systemic pathways. By engaging mitochondrial biology and modulating AMPK and stress response pathways, MOTS-c provides a versatile platform for research into pathway characterization, molecular dynamics, and systemic resilience in laboratory settings.

Lee C. et al., 2015

References

Lee C. et al. (2015). MOTS-c: a mitochondrial-encoded regulator of metabolism and stress response. Cell Metab, 21(3):443–454.

Lee C., Yen K., Cohen P. (2016). Mitochondrial peptides as novel regulators of metabolism. J Physiol, 594(15):5375–5381.

Zhu S. et al. (2017). MOTS-c enhances metabolic homeostasis and mitochondrial function in laboratory models. Aging Cell, 16(5): 968–977.

Kim K.H. et al. (2018). MOTS-c and exercise-induced mitochondrial signaling. J Mol Med, 96(7): 699–709. 

Our Process

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STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

STEP 1

Precision Lyophilization

Manufactured in a controlled U.S. facility under strict compounding standards.

STEP 2

Verified Purity

Every batch third-party tested with HPLC and mass spectrometry.

STEP 3

Same-Day Fulfillment

Orders dispatched same-day from our
U.S. facility.

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Frequently Asked Questions

Everything you need to know about our products and processes.

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Each vial contains exactly what’s shown on the label. For example, a 10mg vial has exactly 10mg of lyophilized peptide. Researchers can divide it into smaller portions—like four 2.5mg measurements—but the total amount remains 10mg.

 
Peptides are supplied as lyophilized powder. They do not come reconstituted, and any extra supplies must be sourced separately for research applications.
 
 
In lyophilized powder form, peptides stay stable for up to 2 years. After reconstitution, it should be refrigerated and is generally stable for up to 2 months.
 
 
Products from us do not include usage instructions, as they are strictly for in vitro research and prohibited by law for human or animal use. Misuse or unlawful application will result in permanent denial of service.
 
 
Lyophilized peptides should be stored away from heat and light. Once reconstituted, they must be refrigerated to maintain stability and efficacy.